Two-carbon extension of N,N-disubstituted amides with bis(trimethylsilyl) thioketene affording N,N-disubstituted 3-oxothioamides
Abstract
N,N-Disubstituted alkanamides cleanly react with bis(trimethylsilyl)thioketene to form N,N-disubstituted 2-trimethylsilyl-3-trimethylsilyloxyalk-2-enethioamides, which upon acid hydrolysis give N,N-disubstituted 3-oxoalkenethioamides.