Asymmetric α-alkylation of α-amino esters using pyridoxal model compounds with a chiral ionophore function; dependence of stereoselectivity on a chelated metal ion

Abstract

Asymmetric α-alkylation of α-amino esters by use of novel pyridoxal model compounds having a chiral ionophore function is studied; the stereoselectivity is specifically induced by Na⁺ and the most effective asymmetric induction occurs with a combination of Na⁺ and an additional chiral ansa-structure.