A new, highly stereoselective approach to pyrrolidines via overall 5-endo-trig cyclisations of homoallylic tosylamides
Abstract
Iodocyclisations of E-homoallylic tosylamides 7 lead to excellent yields of either 2,5-trans-or 2,5-cis-3-iodopyrrolidines (10 or 11), depending upon the reaction conditions.
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