Aziridine 6 is produced highly diastereoselectively by treatment of enantiopure 3-acetoxyaminoquinazolinone 4(Q*NHOAc) with β-trimethylsilylstyren:desilylative elemination of Q* and in situ addition fo cyanide to the intermediate azirine gives the NH-aziridine 8 of 83% ee.
R. S. Atkinson, M. P. Coogan and I. S. T. Lochrie, Chem. Commun., 1996, 789 DOI: 10.1039/CC9960000789
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