Issue 6, 1996

Highly enantioselective synthesis of a chiral 3-quinolylalkanol by an asymmetric autocatalytic reaction

Abstract

A catalytic amount of a chiral zinc alkoxide of 2-methyl-1-(3-quinolyl)propan-1-ol catalyses the enantioselective alkylation of quinoline-3-carbaldehyde by diisopropylzinc to afford 2-methyl-1-(3-quinolyl)propan-1-ol with the same configuration in high ee (up to 94%).

Article information

Article type
Paper

Chem. Commun., 1996, 751-752

Highly enantioselective synthesis of a chiral 3-quinolylalkanol by an asymmetric autocatalytic reaction

T. Shibata, K. Choji, H. Morioka, T. Hayase and K. Soai, Chem. Commun., 1996, 751 DOI: 10.1039/CC9960000751

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