Issue 2, 1996

Incorporation of unnatural amino acid derivatives into a peptide bond via an oxime ester catalysed by papain or lipase

Abstract

In the presence of an oxime in the reaction solution, papain and lipase P (Pseudomonas from Amano) catalysed the stereoselective transesterification of an N-protected amino acid or peptide ester to form an active (oxime) ester which in turn underwent peptide bond formation with several natural and unnatural amino acid derivatives (proline, N-methylglycine, N-methylalanine, α-methylphenylalanine).

Article information

Article type
Paper

Chem. Commun., 1996, 165-166

Incorporation of unnatural amino acid derivatives into a peptide bond via an oxime ester catalysed by papain or lipase

S. Chen, C. Tsai and K. Wang, Chem. Commun., 1996, 165 DOI: 10.1039/CC9960000165

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