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Issue 5, 1996
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Use of a sequential injection technique for mechanistic studies and kinetic determination of bromazepam complexed with iron(II) in hydrochloric acid

Abstract

For the first time a sequential injection technique has been employed in a full kinetic investigation as well as for a kinetic procedure utilizing the fixed-time method. The complexation reaction of bromazepam with iron(II) in hydrochloric acid was studied using spectrophotometric detection at λmax 585 nm for the product formed. A rate law was offered, which was found to be consistent with the postulated reaction mechanism. From the observed kinetics it was found that the fixed-time method utilized at 100 s using 0.0100 mol dm–3 iron(II) and 0.0115 mol dm–3 HCl had optimal conditions for the determination of bromazepam in the range 5.0 × 10–4–1.5 × 10–3 mol dm–3. The method was found to be suitable for the determination of bromazepam in drug formulations.

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Article type: Paper
DOI: 10.1039/AN9962100617
Citation: Analyst, 1996,121, 617-621
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    Use of a sequential injection technique for mechanistic studies and kinetic determination of bromazepam complexed with iron(II) in hydrochloric acid

    S. M. Sultan and F. E. O. Suliman, Analyst, 1996, 121, 617
    DOI: 10.1039/AN9962100617

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