Jump to main content
Jump to site search

Issue 2, 1996
Previous Article Next Article

Development of a stand-alone affinity clean-up for lysergic acid diethylamide in urine

Abstract

A total analysis scheme for lysergic acid diethylamide (LSD) from human urine is described. A simple ELISA technique led to the development and optimization of an affinity clean-up cartridge, resulting in high purification factors with a single combined extraction/clean-up step. LSD can be measured with a straightforward HPLC–fluorescence technique, which minimizes operating complexity and process implementation time. The method has been applied to urine containing 0.5 ng ml–1 LSD, and the ability of high-affinity materials to preconcentrate a sample into a small volume should allow the working range of the procedure to be adjusted as required.

Back to tab navigation

Article information


Analyst, 1996,121, 177-182
Article type
Paper

Development of a stand-alone affinity clean-up for lysergic acid diethylamide in urine

J. M. Francis and D. H. Craston, Analyst, 1996, 121, 177
DOI: 10.1039/AN9962100177

Social activity

Search articles by author

Spotlight

Advertisements