Structure of doramectin
Abstract
The structures of doramectin 1 and its close analogue, 25-cyclohexyl-avermectin B2 2, have been determined by proton and carbon NMR spectroscopy, mass spectrometry and X-ray crystallography. Modern two-dimensional techniques were used to assign the proton and carbon NMR resonances. Several signals in the close-related naturally-occurring avermectins have been re-assigned.