Titanium(IV) mediated reductive aminations of 1-adamantyl methyl ketone: facile preparation of potential antiviral agents rimantadine and its analogues
Abstract
A preparatively efficient, mild method for the synthesis of rimantadine and its analogues via novel reductive aminations of 1-adamantyl methyl ketone using titanium(IV) isopropoxide and sodium borohydride is reported.