Simple and efficient strategy for making β-(1→6)-linked galactooligosaccharides using ‘naked’ galactopyranosides as acceptors

Abstract

Unprotected (naked) galactopyranosides were used for the first time in the direct regio- and stereo-selective synthesis of β-(1→6)-linked oligosaccharides in 75–90% yield by coupling them with acetobromosugars in the presence of silver carbonate in dichloromethane. β-(1→4)-Linked oligosaccharides (yield 5–10%) were the by-products.