Pyrrolidinone 2, pyrimido[1,2-a]benzimidazoles 3a-c and 1,2,4-triazolo[4,3-a]pyrimidine 4 are prepared by condensation of 3-trifluoroacetyl substituted lactams 1a–c with cyclic 1,3-bis-nucleophiles. The nature of the nucleophile determines whether the reaction occurs with or without lactam ring opening.
J. Bouillon, Z. Janousek, H. G. Viehe, B. Tinant and J. Declercq, J. Chem. Soc., Perkin Trans. 1, 1995, 2907 DOI: 10.1039/P19950002907
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