Issue 20, 1995
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Oxidation of some prochiral 3-substituted cyclobutanones using monooxygenase enzymes: a single-step method for the synthesis of optically enriched 3-substituted γ-lactones

René Gagnon,   Gideon Grogan,   Esther Groussain,   Sandrine Pedragosa-Moreau,   Paul F. Richardson,   Stanley M. Roberts,   Andrew J. Willetts,   Véronique Alphand,   Jacques Lebreton  and  Roland Furstoss  

Abstract

Oxidation of the prochiral cyclobutanones 1–5 using Acinetobacter calcoaceticus NCIMB 9871 and Pseudomonas putida NCIMB 10007 monooxygenases (MO1 and MO2) furnishes the corresponding lactones 6–10 in moderate to excellent yield and enantiomeric purity. These enzymes show enantiocomplementarity in all but one case.

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Article information

DOI
https://doi.org/10.1039/P19950002527
Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1995, 2527-2528

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Oxidation of some prochiral 3-substituted cyclobutanones using monooxygenase enzymes: a single-step method for the synthesis of optically enriched 3-substituted γ-lactones

R. Gagnon, G. Grogan, E. Groussain, S. Pedragosa-Moreau, P. F. Richardson, S. M. Roberts, A. J. Willetts, V. Alphand, J. Lebreton and R. Furstoss, J. Chem. Soc., Perkin Trans. 1, 1995, 2527 DOI: 10.1039/P19950002527

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