Formal total syntheses of (–)-oudemansins A, B and X based on a lipase-catalysed hydrolysis of an acetate
Abstract
A highly stereoselective synthesis of versatile chiral synthons possessing two stereogenic centres and based on the enzymic hydrolysis of an acetate, has been achieved and an application of this to the formal total synthesis of (–)-oudemansins A (1), B (2) and X (3) is described.