Metabolites of the higher fungi. Part 28. Globoscinic acid and globoscin, a labile acid–lactone system from Xylaria globosa and Xylaria obovata

Abstract

4-(3′-Acetyl-2′,6′-dihydroxy-5′-methylphenyl)-4-hydroxy-2-methoxybutanoic acid (globoscinic acid) and 5-(3′-acetyl-2′,6′-dihydroxy-5′-methylphenyl)-3-methoxy-2,3,4,5-tetrahydrofuran-2-one (globoscin) have been isolated as mixtures of optically active epimers from the culture media of the fungus Xylaria globosa and the fungus Xylaria obovata. Their structure determination by chemical and physical methods and their labile properties are described.