Dihalogenocarbenes generated using low-valent titanium (LVT) undergo a one-pot cycloaddition to diaryl, aryl alkyl or dialkyl ketones to give α,α-disubstituted acetic acids such as (R,S)-2-arylpropanoic acids. TiI4 proved most effective in this reaction for which the product yield was optimized by use of an excess of reducing agent.
M. García, C. del Campo, E. F. Llama and J. V. Sinisterra, J. Chem. Soc., Perkin Trans. 1, 1995, 1771 DOI: 10.1039/P19950001771
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