Synthesis and biological activity of new C-6 and C-7 substituted vinyloxyimino-penicillins and -cephalosporins

Abstract

The Wittig reaction has been successfully utilized in the preparation of a number of substituted α-vinyloxyiminoacetic acids, the subsequent coupling of which to the 6-APA and 7-ACA nuclei has provided a range of potent β-lactam antibiotics. Development of other procedures for olefin synthesis has broadened the scope, with the preparation of a range of alkenyl-, cycloalkenyl- and arylvinyl-oxyiminoacetamidopenicillins and cephalosporins.