Jump to main content
Jump to site search

Issue 9, 1995
Previous Article Next Article

New syntheses of arylphosphinic acids from the reaction of ethyl diethoxymethylphosphinate with aryl bromides and phenols

Abstract

The chemistry of the hypophosphorous acid synthon, ethyl diethoxymethylphosphinate 1 has been further developed to afford efficient new routes to arylphosphinic acids 6 and 2-hydroxyphenylphosphinic acids 10. In one approach, a palladium(0) catalysed P–H insertion has been used; the second approach utilises a lithium-based ortho rearrangement of aryl phosphonates, readily prepared from the Atherton–Todd reaction of 1 with phenols. In both cases, the phosphinic acids were obtained in a final step by acid deprotection.

Back to tab navigation

Article type: Paper
DOI: 10.1039/P19950001145
J. Chem. Soc., Perkin Trans. 1, 1995, 1145-1151

  •   Request permissions

    New syntheses of arylphosphinic acids from the reaction of ethyl diethoxymethylphosphinate with aryl bromides and phenols

    S. N. L. Bennett and R. G. Hall, J. Chem. Soc., Perkin Trans. 1, 1995, 1145
    DOI: 10.1039/P19950001145

Search articles by author

Spotlight

Advertisements