A new and convenient one-pot synthesis of α,β-unsaturated trifluoromethyl ketones
Abstract
Alkylphosphonates react with N-phenyltrifluoroacetimidoyl chloride in the presence of lithium diisopropylamide to afford mixtures which when treated with aldehydes and subjected to acid hydrolysis afford α,β-unsaturated trifluoromethyl ketones.