Samarium(II) diiodide-mediated intermolecular aldol type reactions of phenacyl bromides with carbonyl compounds

Abstract

Intermolecular aldol type reactions of phenacyl bromides with various carbonyl compounds mediated by samarium(II) diiodide afford β-hydroxy ketones in moderate to good yields. The addition of N,N,N′,N′-tetramethylethylenediamine or diethylaluminium chloride resulted in better yields in some reactions.