Novel preparation of 3-alkyl-5-hydroxy-5-per(poly)fluoroalkyl-4,5-dihydroisoxazoles
Abstract
3-Alkyl-5-hydroxy-5-per(poly)fluoroalkyl-4,5-dihydroisoxazoles have been synthesized by a 1,3-dipolar cycloaddition of trimethylsilyl nitronates to 1-bromo-1-per(poly)fluoroalkylethene via a one-pot or two-step reaction. The reaction was regiospecific and an intermediate containing the trimethylsiloxy group has been isolated.