Improved synthesis of isoguanosine and 6-substituted xanthosine derivatives
Abstract
Isoguanosine 1 was obtained in 76% overall yield starting from 2′,3′,5′-tri-O-acetylxanthosine 3 in a reaction involving the chloro derivative 4 and the N-(purin-6-yl)pyridinium salt derivative 8 which also proved to be new and valuable synthetic intermediates in the obtainment of C-6-substituted xanthosine derivatives.