Jump to main content
Jump to site search

Issue 22, 1995
Previous Article Next Article

Synthesis and properties of mechanism-based inhibitors and probes for inositol monophosphatase derived from 6-O-(2′-hydroxyethyl)-(1R,2R,4R,6R)-cyclohexane-1,2,4,6-tetraol

Abstract

The 1-phosphate, 2′-phosphate and 1, 2′-cyclic phosphate of 6-O-(2-hydroxyethyl)-cyclohexane-1,2,4,6-tetraol are synthesised and found to be good inhibitors of inositol monophosphatase; the stereochemistry of the most potent inhibitor, the (1R,2R,4R,6R)-1-phosphate, provides useful mechanistic insight into the action of this enzyme, the putative target for lithium therapy.

Back to tab navigation

Article type: Paper
DOI: 10.1039/C39950002353
J. Chem. Soc., Chem. Commun., 1995, 2353-2356

  •   Request permissions

    Synthesis and properties of mechanism-based inhibitors and probes for inositol monophosphatase derived from 6-O-(2′-hydroxyethyl)-(1R,2R,4R,6R)-cyclohexane-1,2,4,6-tetraol

    J. Schulz, J. Wilkie, P. Lightfoot, T. Rutherford and D. Gani, J. Chem. Soc., Chem. Commun., 1995, 2353
    DOI: 10.1039/C39950002353

Search articles by author

Spotlight

Advertisements