Ion-channel-forming and catecholamine-releasing activities of elongated and truncated analogues of trichosporin-B
Abstract
Examination of newly synthesized elongated and truncated analogues of the ion-channel-forming peptide, trichosporin-B-VIa (20 residues), for ion-channel-forming activity in lipid bilayer membranes and catecholamine secretion-inducing activity from adrenal chromaffin cells revealed that the natural compound has the optimal molecular length for both activities.