In the addition of silyl enol ethers 8 to α-asymmetric aldehydes 1 and 2, catalysed by ‘supersilylating agents’ R3SiB(OTf)4, †; the level of Cram-type selectivity correlates with the steric bulk of the silyl group; use of the triisopropylsilyl enol ether 8d results in unprecedented levels of 1, 2-asymmetric induction.
A. P. Davis and S. J. Plunkett, J. Chem. Soc., Chem. Commun., 1995, 2173 DOI: 10.1039/C39950002173
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