The phenyl(or p-tolyl)sulfonylmethyl group is introduced with complete regiospecificity to the C-4 position of 3-substituted pyridazines using vicarious nucleophilic substitution of pyridazinium dicyanomethylides.
T. Itoh, Y. Matsuya, K. Nagata, M. Okada and A. Ohsawa, J. Chem. Soc., Chem. Commun., 1995, 2067 DOI: 10.1039/C39950002067
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