Issue 17, 1995

Preparation and study of dinuclear zinc(II) complex for the efficient hydrolysis of the phosphodiester linkage in a diribonucleotide

Abstract

A dinuclear zinc(II) complex with N,N,N′,N′-tetrakis[(2-pyridyl)methyl]-2-hydroxy-1,3-diaminopropane efficiently hydrolyses ApA [adenylyl(3′-5′)adenosine] at pH 7 and 50 °C; the complex can thus be regarded as a good artificial ribonuclease which effectively mimics enzyme active sites.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1995, 1793-1794

Preparation and study of dinuclear zinc(II) complex for the efficient hydrolysis of the phosphodiester linkage in a diribonucleotide

M. Yashiro, A. Ishikubo and M. Komiyama, J. Chem. Soc., Chem. Commun., 1995, 1793 DOI: 10.1039/C39950001793

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