Facile formation of a cis-platin-nonapeptide complex of human DNA polymerase-α origin
Abstract
cis-DDP readily forms a complex with a nonapeptide, E R F K C P C P T, selected from near the DNA binding domain of human DNA polymerase-α, through the two cysteine residues; the reaction is more than an order of magnitude faster than that for the cis-DDP and DNA reaction.