Issue 4, 1995

Enantioselective radical-mediated reduction of α-iodolactone using tributyltin hydride in the presence of a chiral amine and a Lewis acid

Abstract

Enantioselective radical-mediated reduction of α-methoxymethyl-α-iododihydrocoumarin 1 using tributyltin hydride is realized in up to 62% enantiomeric excess (e.e.)(88% chemical yield) by combination of chiral diamine 2 and magnesium iodide.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1995, 481-482

Enantioselective radical-mediated reduction of α-iodolactone using tributyltin hydride in the presence of a chiral amine and a Lewis acid

M. Murakata, H. Tsutsui and O. Hoshino, J. Chem. Soc., Chem. Commun., 1995, 481 DOI: 10.1039/C39950000481

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