Approaches to the assembly of the antifungal agent FR-900848: studies on the synthesis of C2 symmetric tetracyclopropane derivatives and an X-ray crystallographic study of (1R,3S,4S,6R)-bicyclopropyl-1,6-di-{2-[(4R,5R)-di-(isopropyloxycarbonyl)-1,3-dioxolane]}
Abstract
Two sequential asymmetric bicyclopropanation reactions were used to prepare (1R,3S,4R,6S,7S,9R,10S,12R)-quatercyclopropyl-1,12-dimethanol and (1S,3R,4R,6S,7S,9R,10R,12S)-quatercyclopropyl-1,12-dimethanol.