Issue 2, 1995

Enantioselective syntheses of (S)- and (R)-3-hydroxypyrrolidin-2-ones via lactate dehydrogenase catalysed reductions of 4-benzyloxycarbonylamino-2-oxobutanoic acid

Abstract

The first examples of the BS- and SE-lactate dehydrogenase catalysed reductions of an α-keto acid incorporating a nitrogen containing function in the side chain are described: (S)- and (R)-benzyloxycarbonylamino-2-hydroxybutanoic acids were prepared in good yield and excellent enantioselectivities and were converted to the (S)- and (R)-3-hydroxypyrrolidin-2-ones respectively.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1995, 231-232

Enantioselective syntheses of (S)- and (R)-3-hydroxypyrrolidin-2-ones via lactate dehydrogenase catalysed reductions of 4-benzyloxycarbonylamino-2-oxobutanoic acid

J. M. Bentley, H. J. Wadsworth and C. L. Willis, J. Chem. Soc., Chem. Commun., 1995, 231 DOI: 10.1039/C39950000231

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