Total synthesis of 2′-deoxy-2′-arafluorotoyocamycin and related nucleosides
Abstract
Total synthesis of 2′-deoxy-2′-arafluoro analogues of toyocamycin 11, sangivamycin 12 and thiosangivamycin 13, starting from 5-bromo-2-ethoxymethyleneaminopyrrole-3,4-dicarbonitrile 4 has been accomplished for the first time.