A cyclization reaction catalysed by antibodies
Abstract
Monoclonal antibodies, elicited by transition-state analogues for either exo- or endo-lactonization of α-trifluoromethyl-γ,δ-unsaturated acids, catalyse the regiospecific formation of corresponding γ- or δ-lactones; the exo-lactonization proceeds with high diastereospecificity.