Atomic emission spectrometric determination of antazoline, hydralazine and amiloride hydrochlorides, and quinine sulfate based on formation of ion associates with manganese thiocyanate

Abstract

Ion associate complexes of the hydrochlorides of antazoline (1), hydralazine (2) and amiloride (3), and quinine sulfate (4) with [Mn(SCN)₄]^2– were precipitated and their solubilities were studied as a function of pH, ionic strength and temperature. The optimum conditions for the complete precipitation of the ion associate were, thus, elucidated. An accurate and precise method using atomic emission spectrometry for the determination of the investigated drugs in pure solutions and in pharmaceutical preparations is reported. The drugs can be determined by this method in the ranges 0.3–3.0, 0.19–1.96, 0.3–3.0 and 0.78–7.82 mg per 25 ml solutions of (1), (2), (3) and (4), respectively.