Analysis of blood sodium using flow injection analysis with a calix[4]arene potentiometric detector

Abstract

Flow injection analysis with potentiometric ion selective electrode detection is discussed in the context of sodium analysis in blood samples. A novel ionophore is used, which shows excellent selectivity for sodium over common interferents. Several blood samples are analysed and a very good correlation is demonstrated between the concentrations estimated and those determined by standard hospital procedures. Preliminary studies have indicated an ion selective electrode which could potentially be used for analysis of diluted blood samples without any correction for matrix effects.