Cathodic stripping voltammetric determination of sulfonamides as copper(I) complexes at a hanging mercury drop electrode

Abstract

Sulfonamides that form stable metal complexes can be accumulated at a hanging mercury drop electrode in the presence of copper(II). In this preliminary study sulfadimidine, sulfathiazole, sulfamerazine, sulfadiazine and sulfapyridine, which have an ortho heterocyclic nitrogen atom on the ring attached to the sulfonamide nitrogen atom, and which are known to form stable complexes with copper(II), have been accumulated in this way and have been determined indirectly by reduction of the complexed copper to copper amalgam. Sulfanilamide, sulfaguanidine and sulfacetamide, which do not form stable complexes, are not accumulated. Preliminary results indicate that the sulfonamides are accumulated as their copper(I) complexes