Peroxidatic activity of haem octapeptide complexes with anilines, naphthols and phenols

Abstract

Complexation of the title substrates to microperoxidase-8 (MP-8) results in inhibition of the normal MP-8 catalytic pathway, but introduces an alternative pathway, probably leading to the same oxidised intermediate. This pathway must involve a different type of H₂O₂–MP-8 interaction to that proposed for HRP, and a preliminary interaction of peroxide with the porphyrin ring, rather than the Fe, of the MP-8:substrate complex is suggested for this pathway.