Kinetic study on the hydrolysis of thiazolium cations

Abstract

Using the stopped-flow technique the hydrolysis of ten differently substituted thiazolium cations has been studied. For all compounds the hydrolysis follows the same reaction scheme leading to a ring-opened anion. A pseudo base, the protonated pseudo base and the protonated ring-opened anion exist as intermediates. Rate and equilibrium constants were determined for the different steps involved in the reaction.