Biosynthesis of aristeromycin: the role of (1R, 2R, 3S, 4S)-1-hydroxymethylcyclopentane-2,3,4-triol
Abstract
(1R, 2R, 3S, 4S)-1-Hydroxymethylcyclopentane-2,3,4-trio 2, a possible precursor of aristeromycin 1 was synthesised in tritiated form and administered to Streptomyces citricolor. Radioactivity was incorporated into aristeromycin, but degradation showed that incorporation of radioactivity was nonspecific, indicating that the tetrol 2 is not an immediate precursor of aristeromycin 1.