The Claisen rearrangement of the vinyl substituted ketene aminals 2(R = CH2CHMe2, CH2OSiButMe2) which were generated in situ by selenoxide elimination of the aminal precursors 3 in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) furnished the enantiomerically pure 7-substituted tetrahydroazepin-2-ones 1.
P. A. Evans, A. B. Holmes and K. Russell, J. Chem. Soc., Perkin Trans. 1, 1994, 3397 DOI: 10.1039/P19940003397
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