Maxi-K (large-conductance calcium-activated potassium)channels are a family of proteins which are thought to play an important role in controlling the contractility of airway smooth muscle. Maxikdiol is a novel, 1,5-dihydroxyisoprimane, diterpenoid which acts as an agonist of the channel. The isolation, structure elucidation and biological activity of maxikdiol are described.
S. B. Singh, M. A. Goetz, D. L. Zink, A. W. Dombrowski, J. D. Polishook, M. L. Garcia, W. Schmalhofer, O. B. McManus and G. J. Kaczorowski, J. Chem. Soc., Perkin Trans. 1, 1994, 3349 DOI: 10.1039/P19940003349
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