Biosynthesis of (1S)-7-methoxy-1,2-dihydrocadalene. Incorporation of 2H- and 13C-labelled mevalonates by cultured cells of Heteroscyphus planus
Abstract
2 H and 13C NMR analyses of (1S)-7-methoxy-1, 2-dihydrocadalene produced by cell cultures of the liverwort Heteroscyphus planus in the presence of 2H- and 13C-labelled mevalonates verified 1,2 and 1,3-hydride shifts and the hydroxylation of an aromatic ring without an NIH shift in the biosynthesis of MDC.