Biosynthesis of astellatol, a novel rearranged sesterterpenoid metabolite of Aspergillus variecolor
Abstract
The labelling pattern arising from incorporation of [1,2-13C2]acetate into astellatol, a novel sesterterpenoid fungal metabolite, supports its biosynthesis via cyclisation and subsequent rearrangement of geranylfarnesyl pyrophosphate, and allows its relationship to a number of other fungal sesterterpenoids to be proposed.