The total synthesis of (+)-dihydrocompactin 1 has been achieved by employing double Michael reaction of 3-(tert-butyldimethylsiloxy)-1-acetylcyclohexene 13 with methyl crotonate and the TiCl4-promoted aldol condensation of the bis(trimethylsilyl enol ether) of methyl acetoacetate 7 as key reactions.
H. Hagiwara, M. Kon-no, T. Nakano and H. Uda, J. Chem. Soc., Perkin Trans. 1, 1994, 2417 DOI: 10.1039/P19940002417
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