Reactivity of carbocyclic four-membered radicals for the preparation of carbocyclic analogues of oxetanocins

Abstract

New carbocyclic four-membered C-nucleosides have been synthesized from the corresponding carboxylic acids and heteroaromatic compounds by the use of the Barton radical reaction. These carbocyclic nucleosides are analogues of oxetanosyl and cyclobutyl N-nucleosides which exhibit potent antiviral activities. The present synthetic routes provide a method for the preparation of cyclobutyl C-nucleosides.