A 4-triazolyl substituted pyrimidine nucleoside undergoes nucleophilic displacement with the sodium salts of amides and thiols at room temperature in 1,4-dioxane exclusively at the 4-position to provide a simple and efficient preparation of 4-N-acylated and 4-thiolated analogues, respectively.
M. Perbost and Y. S. Sanghvi, J. Chem. Soc., Perkin Trans. 1, 1994, 2051 DOI: 10.1039/P19940002051
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