Bridgehead substitution of 1-methoxybicyclo[2.2.2]oct-5-en-2-one derivatives: towards the synthesis of (±)-allo-cedrol [khusiol]1
Abstract
Preparation of the key intermediates, 11 and 21, required for the synthesis of (±)-allo-cedrol (khusiol) is reported by a novel methodology involving the substitution at the bridgehead position of 1-methoxybicyclo[2.2.2.]oct-5-en-2-one derivatives.