Palladium(II) catalysed 5-endo-trigonal cyclization of 2-hydroxybut-3-enylamines: synthesis of five-membered nitrogen heterocycles
Abstract
2-Hydroxybut-3-enylamines 1 undergo a novel PdII-catalysed 5-endo-trigonal cyclization to provide pyrrolines 2, pyrroles 3, and/or 3-oxopyrrolidines 4 in good to moderate combined isolated yields; the hydroxy group is essential for the cyclization.