Issue 17, 1994

A route to dipeptides containing β-amino-α-hydroxy acid fragments by coupling of N-boc-β-lactams with α-amino esters. Application to the synthesis of (–)-bestatin

Abstract

α-Amino esters are smoothly acylated by N-Boc-3-alkoxy-4-alkyl-β-lactams in DMF under the influence of sodium azide, giving a novel dipeptide coupling reaction.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1994, 1957-1958

A route to dipeptides containing β-amino-α-hydroxy acid fragments by coupling of N-boc-β-lactams with α-amino esters. Application to the synthesis of (–)-bestatin

C. Palomo, J. M. Aizpurua and C. Cuevas, J. Chem. Soc., Chem. Commun., 1994, 1957 DOI: 10.1039/C39940001957

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