Ethyl (8-carbamoyl-3,4-dihydro-4-oxoimidazo[5,1,-d]-1,2,3,5-tetrazin-3-yl)acetate 5 can be prepared by two rotes starting from 5-aminoimidazole-4-carboxamide 2; hydrolysis of 5 to the coressponding carbozylic acid 6 followed by Barton radical decraboxylation gives the antitumour imidazotetrazinone temozolomied 1.
Y. Wang, M. F. G. Stevens and W. Thomson, J. Chem. Soc., Chem. Commun., 1994, 1687 DOI: 10.1039/C39940001687
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